Venmans et al., Chest, Vol. 117, 2000

Outcome of Bronchial Carcinoma In Situ

- Squamous cell carcinoma of the bronchus arises after a serios of progressive histological changes in the epithelium. These are in the order of increasing severity:

• basal cell metaplasia
• metaplasia
• dysplasia:
  
• mild
• moderate
• severe
• carcinoma in situ

The extent to which these lesinos precede one another in time and their precise outcome remain largely unknown.